A nice way to wrap up 2014–we have a new paper out [cite source=’pubmed’]25486125[/cite] where we trace learning-induced changes in transcription over time and over different location in the CNS. We think it’s a nice follow-up to the microarray paper, because:
The Sluglab went to Washington D.C. for the 2014 Meeting of the Society for Neuroscience. This is either the 13th or 14th time Irina and I have been. Despite the mileage, we had a great meeting, and enjoyed seeing Sami shine in her first big-time presentation of her work in the lab. Good work, Sami!
We’ve got a new paper out [cite source=’pubmed’]25117657[/cite] with the first of what we hope will be a series of studies using microarray to track the transcriptional changes following long-term sensitization training. This paper looks at the changes that occur immediately (1 hour) after training. It provides lots of details and data to validate the microarray design we developed, but also identifies a set of 81 transcripts that are strongly regulated after learning. Best of all, for a microarray paper, we use a large sample size (n = 8) and show using a subset of transcripts that most generalize to a completely independent sample. Among the changes we fully validated are up-regulation of a c/ebp-gamma (what the what!?), a glycine transporter, and a subunit of ESCRTII. The rest of the gene list that we’re working on has some exciting possibilities, too.
Another thing to be proud of, is our three student co-authors on the paper.
The paper is free for the next 50 days via this link, then it goes behind a paywall for 305 days, then it will be in PubMedCentral for free again (strange, right?). All the raw data is available on the Open Science Framework: https://osf.io/8pgfh/.
Congratulations, Gerry! Junior DU student, bio major, and all-around Slug Lab superstar won a Faculty for Undergraduate Neuroscience Travel Award to attend this year’s Society for Neuroscience Meeting in San Diego, CA. It was a competitive and international field, but Gerry nabbed one of these prestigious awards to present her ongoing work on the transcriptional mechanisms of long-term habituation. Shown in the photo on the left is Gerry (left), Dr C-J (middle) and lab alumni Kristine Bonnick (right) who visisted the poster and the meeting from Loma Linda medical school where she is now enrolled. In the photo on the right, Dr. Bob makes an appearance. Go sluglab!
Our lab has had a couple of great write-ups in the local news: