Harmonin inhibits presynaptic Cav1.3 Ca²⁺ channels in mouse inner hair cells

Gregory FD, Bryan KE, Pangršič T, Calin-Jageman IE, Moser T, Lee A

Nat. Neurosci. 2011 Sep;14(9):1109-11

PMID: 21822269

Abstract

Harmonin is a scaffolding protein that is required for normal mechanosensory function in hair cells. We found a presynaptic association of harmonin and Ca(v)1.3 Ca(2+) channels at the mouse inner hair cell synapse, which limits channel availability through a ubiquitin-dependent pathway.

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